Zai-Sheng Wu
Postdoctoral Fellow
Ph.D. Analytical Chemistry, Hunan University, China, 2008
M.Sc. Analytical Chemistry, Hunan University, China, Transferred to doctorate in 2005
B.Sc. Chemical Education, Hunan University of Arts and Science, China, 1997
Department of Biochemistry and Biomedical Sciences
McMaster University
Health Science Centre, Room 4H31B
1280 Main Street West
Hamilton, Ontario, L8S 4K1
905.525.9140 ext.22757 | ext.28813
905.522.9033
wuzai@mcmaster.ca
Brief Biography:
Zai-Sheng Wu received his PhD degree in analytical chemistry at Hunan University in 2008 and became a postdoctoral fellow in the Li Lab at McMaster University in 2010. His principal research interests focus on nucleic acid chemistry and biology. He has more than 40 publications, including 14 papers with the IF of above 5. He received the First Prize of the Natural Science Award by the Ministry of Education of China, the Michael G. DeGroote Fellowship Award by McMaster University, and various other awards. Three of his projects (in which he is either the leader or an important investigator) are funded by the National Nature Science foundation of China (NSFC). He is also often invited to contribute chapters to important books, submit articles to international journals and review manuscripts submitted to impressive journals.
"The word scientist means...an innovative personality, creative abilities, matter-of-fact attitude and significant scientific contribution to basic or applied research."
Research Interests:
- Construction of functional nucleic acid-based assay systems for disease diagnostics, biomarker screening, drug discovery and environmental monitoring
- Design of robust nucleic acid probes and DNA biosensors for mutant targets associated with genetic diseases
- Development and application of DNA nanostructures
- Nanobiotechnology and immunoassay
Awards:
- Michael G. DeGroote Fellowship Award by McMaster University, January 2011
- Outstanding Ph.D. Thesis Award by Hunan Province, December 2010
- The Eleventh Young Scholar Award by Hunan Province for Chemistry/Chemical Engineering, July 2010
- Outstanding Ph.D. Thesis Award by Hunan University, July 2010
- The First Prize of the Natural Science Award by the Ministry of Education of China, January 2009
- The First Foundation for the Awarding of Excellent Doctoral Dissertation from Hunan University, September 2006
Publications:
41.
Li-Ping Qiu, Zai-Sheng Wu*, Guo-Li Shen, and Ru-Qin Yu*, Highly Sensitive and
Selective Bifunctional Oligonucleotide Probe for Homogeneous Parallel Fluorescence Detection of Protein and Nucleotide Sequence, Analytical Chemistry, 2011, 83, 3050–
3057.
40.
Zai-Sheng Wu,* Song-Bai Zhang, Guo-Li Shen* and Ru-Qin Yu, Robust
electrochemical system for screening single nucleotide polymorphisms Rong Hu, Chemical Communications, 2010, 46, 2232–2234.
39.
Jing-Lin He, Zai-Sheng Wu,* Hui Zhou, Hong-Qi Wang, Jian-Hui Jiang, Guo-Li Shen, and Ru-Qin Yu*. Fluorescence Aptameric Sensor for Strand Displacement Amplification Detection of Cocaine. Analytical Chemistry, 2010, 82, 1358–1364.
38.
Zai-Sheng Wu, Hui Zhou, Songbai Zhang, Guoli Shen, and Ruqin Yu. Electrochemical Aptameric Recognition System for a Sensitive Protein Assay Based on Specific Target Binding-Induced Rolling Circle Amplification. Analytical Chemistry, 2010, 82 (6), 2282–2289.
37.
Zai-Sheng Wu, Songbai Zhang, Hui Zhou, Guo-Li Shen, and Ruqin Yu. Universal Aptameric System for Highly Sensitive Detection of Protein Based on Structure-Switching-Triggered Rolling Circle Amplification. Analytical Chemistry, 2010, 82 (6), 2221–2227.
36.
Zai-Sheng Wu, Haixia Lu, Xueping Liu, Rong Hu, Hui Zhou, Guoli Shen, and Ru-Qin Yu. Inhibitory Effect of Target Binding on Hairpin Aptamer Sticky-End Pairing-Induced Gold Nanoparticle Assembly for Light-up Colorimetric Protein Assay. Analytical Chemistry, 2010, 82, 3890–3898.
35.
Songbai Zhang, Rong Hu, Peng Hu, Zai-Sheng Wu,* Guo-Li Shen,* and Ru-Qin Yu, Background current-free electrochemical aptameric sensing platform for ultrasensitive signal-on detection of small molecule, Nucleic Acids Research, 2010, 38 (20), e185.
34.
Zai-Sheng Wu, Hui Zhou, Songbai Zhang, Xiaobing Zhang, Guoli Shen and Ruqin Yu, Pendulum-type optical DNA nanodevice, Chemical Communications, 2010, 46, 2232–2234.
33.
Zai-Sheng Wu, Peng Hu, Hui Zhou, Guoli Shen and Ruqin Yu, Fluorescent oligonucleotide probe based on G-quadruplex scaffold for signal-on ultrasensitive protein assay, Biomaterials 2010, 31(7), 1918–1924.
32.
Songbai Zhang, Zai-Sheng Wu,* Liping Qiu, Hui Zhou, Guoli Shen* and Ruqin Yu, G-quadruplex signaling probe for highly sensitive DNA detection, Chemical Communication, 2010, 46, 3381–3383.
31.
Chenrui Chen, Dengyou Liu, Zaisheng Wu,* Qimei Luo, Guo-Li Shen and Ru-Qin Yu, Sensitive label-free electrochemical immunoassay by electrocatalytic amplification. Electrochemistry Communications, 2009, 11(10), 1869-1872.
30.
Zai-Sheng Wu, Fan Zheng, Guo-Li Shen, Ru-Qin Yu, A hairpin aptamer-based electrochemical biosensing platform for the sensitive detection of proteins. Biomaterials 2009, 30 (15), 2950-2955.
29.
Zai-Sheng Wu,* Chen-Rui Chen, Guo-Li Shen and Ru-Qin Yu, Reversible electronic nanoswitch based on DNA G-quadruplex conformation: a platform for single-step, reagentless potassium detection, Biomaterials, 2008, 29(17), 2689-2696.
28.
Zai-Sheng Wu, Meng-Meng Guo, Song-Bai Zhang, Chen-Rui Chen, Jian-Hui Jiang, Guo-Li Shen and Ru-Qin Yu, Reusable electrochemical sensing platform for highly sensitive detection of small molecules based on structure-switching signaling aptamers, Analytical Chemistry, 2007, 79(7), 2933-2939.
27.
Zai-Sheng Wu, Jian-Hui Jiang, Guo-Li Shen, and Ru-Qin Yu, Highly sensitive DNA detection and point mutation identification: an electrochemical approach based on the combined use of ligase and reverse molecular beacon, Human Mutation, 2007, 28(6): 630-637.
26.
Yuehua Fei, Xiao-Yong Jin, Zai-Sheng Wu,∗ Song-Bai Zhang, Guoli Shen,∗ Ru-Qin Yu, Sensitive and selective DNA detection based on the combination of hairpin-type probe with endonuclease/GNP signal amplification using quartz-crystal-microbalance transduction, Analytica Chimica Acta, 2011, 691, 95-102.
25.
Li-Ping Qiu, Cun-Chang Wang, Peng Hu, Zai-Sheng Wu,∗ Guo-Li Shen, Ru-Qin Yu∗, A label-free electrochemical immunoassay for IgG detection based on the electron transfer, Talanta, 2011, 83, 42-47.
24.
Dengyou Liu, Zhixi Gao, Qimei Luo, Zai-Sheng Wu,* Conductive three-dimensional ordered nano-gold film: Ultrasensitive electrochemical sensing platform for clinical immunoassay, Talanta, 2010, 82(4), 1175-1180.
23.
Zai-Sheng Wu, Meng-Meng Guo, Guo-Li Shen and Ru-Qin Yu, G-rich oligonucleotide-functionalized gold nanoparticle aggregation, Anal. Bioanal. Chem., 2007, 387(8), 2623-2626.
22.
Zai-Sheng Wu, Song-Bai Zhang, Meng-Meng Guo, Chen-Rui Chen, Guo-Li Shen and Ru-Qin Yu. Homogeneous, unmodified gold nanoparticle-based colorimetric assay of hydrogen peroxide, Analytica Chimica Acta, 2007, 584(1), 122-128.
21.
Zai-Sheng Wu, Gu-Zhen Zhou, Jian-Hui Jiang, Guo-Li Shen and Ru-Qin Yu, Gold colloid-bienzyme conjugates for glucose detection utilizing surface-enhanced Raman scattering, Talanta, 2006, 70(3), 533-539.
20.
Zai-Sheng Wu, Jian-Hui Jiang, Li Fu, Guo-Li Shen and Ru-Qin Yu, Optical detection of DNA hybridization based on fluorescence quenching of tagged oligonucleotide probes by gold nanoparticles, Analytical Biochemistry, 2006, 353(1), 22-29.
19.
Zai-Sheng Wu, Ji-Shan Li, Ting Deng, Ming-Hui Luo, Guo-Li Shen and Ru-Qin Yu, A sensitive immunoassay based on electropolymerized films by capacitance measurements for direct detection of immunospecies, Analytical Biochemistry, 2005, 337(2), 308-315.
18.
Zai-Sheng Wu, Ji-Shan Li, Ming-Hui Luo, Guo-Li Shen and Ru-Qin Yu, A novel capacitive immunosensor based on gold colloid monolayers associated with a sol–gel matrix, Analytica Chimica Acta, 2005, 528(2), 235-242.
17.
Wu Zai-Sheng, Li Ji-Shan, Luo Ming-Hui, Shen Guo-Li*, Yu Ru-Qin, A Novel Regenerative Capacitive Immunosensor Based on Electrostatic Attraction for Direct Detection of the Complement Ⅲ(C3), Chemical Researches in Chinese Universities, 2005, 26(3): 441-445.
16.
Jian Tang, Rong Hu, Zai-Sheng Wu, Guo-Li Shen, Ru-Qin Yu, A highly sensitive electrochemical immunosensor based on coral-shaped AuNPs with CHITs inorganic–organic hybrid film, Talanta, 2011, Available online.
15.
Kejun Feng, Jingjin Zhao, Zai-Sheng Wu, Jianhui Jiang, Guoli Shen, Ruqin Yu, High-sensitive electrochemical detection of point mutation based on polymerization-induced enzymatic amplification, Biosensors and Bioelectronics, 2011, 26 (7), 3187-3191.
14.
Xue-Ping Liu，Hui-Wang Wu, Yue Zheng, Zai-Sheng Wu, Jian-Hui Jiang, Guo-Li Shen, Ru-Qin Yu. A sensitive electrochemical immunosensor for AFP detection with colloidal gold-based dentritical enzyme complex amplification. Electroanalysis, 2010, 22: 244-250.
13.
Jing-Lin He, Zai-Sheng Wu, Peng Hu, Sui-Ping Wang, Guo-Li Shen and Ru-Qin Yu, Biocatalytic growth of gold agglomerates on an electrode for aptamer-based electrochemical detection. Analyst, 2010, 135, 570-576.
12.
Jing-Lin He, Zai-Sheng Wu, Song-Bai Zhang, Guo-Li Shen, Ru-Qin Yu, Fluorescence aptasensor based on competitive-binding for human neutrophil elastase detection, Talanta, 2010, 80, 1264-1268.
11.
Limin Lu, Li Zhang, Xiaobing Zhang, Zai-Sheng Wu, Shuangyan Huan, Guoli Shen, Ruqin Yu, A MgO Nanoparticles Composite Matrix-Based Electrochemical Biosensor for Hydrogen Peroxide with High Sensitivity, Electroanalysis, 2010, 22, 471-477.
10.
Zhang Song-Bai; Wu Zai-Sheng; Xie Ming; Shen Guo-Li*; Yu Ruqin, Homogeneous detection of DNA hybridization based on fluorescence quenching by gold nanoparticle in single-step format: target-induced configuration transform. Chinese Journal of Chemistry, 2009, 27(3): 523-528.
9.
Lu Hai-Xia, Wu Zai-Sheng, Jin Xiao-Yong, Shen Guo-Li, Yu Ru-Qin, A Novel Electrochemical Sensor Based on Seminetwork-type Au Nanoparticles labled horseradish peroxidase, Chemical Researches in Chinese Universities, 2009, 30(2): 263-267.
8.
Jing-Lin He, Zai-Sheng Wu, Song-Bai Zhang, Fan Zheng, Guo-Li Shen, and Ru-Qin Yu, Novel fluorescence enhancement IgE assay using a DNA aptamer, Analyst, 2009, 134(5), 1003-1007.
7.
Song-Bai Zhang, Zai-Sheng Wu, Guo-Li Shen, Ru-Qin Yu, A label-free strategy for SNP detection with high fidelity and sensitivity based on ligation-rolling circle amplification and intercalating of methylene blue, Biosensors and Bioelectronics, 2009, 24, 3201-3207.
6.
Li-Min Lu, Li Zhang, Feng-Li Qu, Hai-Xia Lu, Xiao-Bing Zhang, Zai-Sheng Wu, Shuang-Yan Huan, Qiu-An Wang, Guo-Li Shen and Ru-Qin Yu, A nano-Ni based ultrasensitive nonenzymatic electrochemical sensor for glucose: Enhancing sensitivity through a nanowire array strategy, Biosensors and Bioelectronics, 2009, 25(1):218-223.
5.
Suiping Wang, Zaisheng Wu, Fengli Qu, Songbai Zhang, Guoli Shen, Ruqin Yu, A novel electrochemical immunosensor based on Au nano-prickle clusters, Biosensor and Bioelectronics, 2008, 24(4), 1026-1032 .
4.
Fan Zheng, Zai-Sheng Wu, Song-bai Zhang, Meng-meng Guo, Chen-rui Chen, Guo-li Shen, and Ru-qin Yu, Aptamer-based Electrochemical Biosensors for Highly Selective and Quantitative Detection of Adenosine, Chemical Research in Chinese Universities, 2008, 24(2), 138-142.
3.
Song-Bai Zhang, Fan Zheng, Zai-Sheng Wu, Guo-Li Shen, Ru-Qin Yu, Highly sensitive electrochemical detection of immunospecies based on combination of Fc label and PPD film/gold nanoparticle amplification, Biosensors and Bioelectronics, 2008, 24, 129-135.
2.
Song-Bai Zhang, Zai-Sheng Wu, Meng-Meng Guo, Guo-Li Shen and Ru-Qin Yu, A novel immunoassay strategy based on combination of chitosan and a gold nanoparticle label, Talanta, 2007, 71(4), 1530-1535.
1.
Ji-Shan Li, Zai-Sheng Wu, Hua Wang, Gu-Lli Shen, and Ru-Qin Yu, A reusable capacitive immunosensor with a novel immobilization procedure based on 1,6-hexanedithiol and nano-Au self-assembled layers, Sensors and Actuators B: Chemical, 2005, 110(2): 327-334.
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